2020-03-18 at 14:00
Conference Room UCL R+0
Connectivity and plasticity of a prominent inhibitory interneuron of the neocortex
In the neocortex, perisomatic inhibition onto principal pyramidal neurons (PNs) determines the dynamic range of pyramidal neuron responses during sensory processing and drive several forms of network oscillations, believed to be the network correlate of several cognitive functions. The inhibitory control of the perisomatic region of PNs originates mainly from a GABAergic interneuron subtype the: parvalbumin (PV)-expressing basket cell. I will describe a PV cell-specific microcircuit: autaptic self-inhibition, which represents an exceptionally large and fast disinhibitory mechanism, favoring synchronization of PV-cell firing during cognitive-relevant cortical network activity. I will also discuss how activity-dependent plasticity of perisomatic inhibition effectively influences the participation of single PNs to γ-oscillations. This work highlights specific strategies operated by PV cells in controlling the output spikes of PNs during cortical activity.
To be provided.