Angelo Arleo is a Director of Research (DR2) at CNRS and a team leader at the Vision Institute, Paris, where he explores the perceptual and cognitive consequences of visual aging in humans. He is the Chairholder of the ANR–Essilor research chair SILVERSIGHT, which pioneers fundamental research on healthy visual aging, action and autonomy to foster innovative health care developments.
His research is primarily centred on the neural processes mediating multisensory integration, contextual learning, and spatial cognitive functions. He also focuses on adaptive neural computation and brain information processing. His approach combines experimental neuroscience and computational modelling to cross-link different organization levels, from single cell to behaviour. In addition, the validation of models through robotic implementations inscribes some aspects of his research within a neuroengineering framework.
He received a MSc degree from the University of Mathematical Science of Milan, Italy, in 1996. He joined Wulfram Gerstner’s Laboratory of Computational Neuroscience at the EPFL (Swiss Federal Institute of Technology Lausanne, Switzerland) where he received his PhD in 2000. He did a postdoctoral training in experimental neuroscience in Alain Berthoz’s Laboratory of Physiology of Perception and Action at Collège de France, Paris, from 2001-2003. He worked as an associate R&D fellow at CSL Sony, Paris, from 2004 to 2006. He received his Habilitation to Direct Research (HDR) in Life Science from the University Pierre and Marie Curie, Paris, in 2005. He was appointed as a CNRS researcher in 2006. From 2007 to 2013 he directed the Adaptive NeuroComputation (ANC) group in the unit of Neurobiology of Adaptive Processes, directed by Jean Mariani, at the University Pierre & Marie Curie, in Paris. In 2012 he was appointed as a Director of Research at CNRS. In 2014, he joined the Vision Institute, directed by José-Alain Sahel, as the head of the new Aging in Vision and Action research lab.
Keywords: Healthy aging, spatial cognition, active exploration, multisensory integration, neural coding, learning mechanisms, memory, experimental neuroscience, neurocomputational modelling, autonomy loss, visual aids, rehabilitation.
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Publications
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2023
- The vertical position of visual information conditions spatial memory performance in healthy aging. Communications Psychology, 1:2. (2023)
- Consensus Paper: Cerebellum and Ageing. The Cerebellum. (2023)
- Landmark-based spatial navigation across the human lifespan. eLife, 12:e81318. (2023)
- Long-term memory, synaptic plasticity, and dopamine in rodent medial prefrontal cortex: Role in executive functions. Frontiers in Behavioral Neuroscience, (in press). (2023)
2022
- The vertical position of visual information conditions spatial memory performance in healthy aging. BioRxiv Preprint. (2022)
- Selective neural coding of object, feature, and geometry spatial cues in humans. Human Brain Mapping. (2022)
- An appraisal of the role of the neocerebellum for spatial navigation in healthy aging. The Cerebellum. (2022)
- Future trends in brain aging research: visuo-cognitive functions at stake during mobility and spatial navigation. Aging Brain, 2:100034. (2022)
- Electrical coupling regulated by GABAergic nucleo- olivary afferent fibres facilitate cerebellar sensory-motor adaptation. Neural Networks, 155:422-438. (2022)
- Computational epidemiology study of homeostatic compensation during sensorimotor aging. Neural Networks, 146:316-333. (2022)
2021
- Mobile brain/body imaging of landmark-based navigation with high-density EEG. European Journal of Neuroscience, 54(12):8256-8282. (2021)
- Variance-dependent neural activity in an unvoluntary averaging task. Attention, Perception, and Psychophysics, 83:1094-1105. (2021)
- Functionally Assessing the Age-Related Decline in the Detection Rate of Photons by Cone Photoreceptors. Frontiers in Aging Neuroscience, 13:870. (2021)
- The false aperture problem: Global motion perception without integration of local motion signals. Psychological Review (in press). (2021)
- Partial recovery of visual function in a blind patient after optogenetic therapy. Nature Medicine, doi:10.1038/s41591-021-01351-4. (2021)
- A new method for visualizing drusen and their progression in adaptive optics ophthalmoschopy. Translation Vision Science & Technology, 10(14):19. (2021)
2020
- Differential Brain Activity in Regions Linked to Visuospatial Processing During Landmark-Based Navigation in Young and Healthy Older Adults. Frontiers in Human Neuroscience, 14:552111. (2020)
- Modulation of spatial cue processing across the lifespan: a geometric polarization of space restores allocentric navigation strategies in children and older adults. bioRxiv. (2020)
- Age-related preference for geometric spatial cues during real-world navigation. Nature Human Behaviour, 4(1):88-99. (2020)
- A model of a panoramic visual representation in the dorsal visual pathway: the case of spatial reorientation and memory-based search. bioRxiv. (2020)
- Modeling place cells and grid cells in multi-compartment environments: hippocampal-entorhinal loop as a multisensory integration circuit. Neural Networks, 121:37-51. (2020)
- Postural control while walking interferes with spatial learning in older adults navigating in a real Environment. Frontiers in Aging Neuroscience, 12:588653. (2020)
- A computational model of homeostatic cerebellar compensation of ageing in vestibulo-ocular reflex adaptation. bioRxiv. (2020)
- VOR adaptation on a humanoid iCub robot using a spiking cerebellar model. IEEE Trans Cybern, 50(11):4744-57. (2020)
- Age-related decline in motion contrast sensitivity due to lower absorption rate of cones and calculation efficiency. Scientific Reports, 10(1):16521. (2020)
- New technologies for outcome measures in glaucoma: review by the European Vision Institute Special Interest Focus Group. Ophthalmic Research, 63:88-96. (2020)
2019
- Age-related differences in functional and structural connectivity in spatial navigation brain network. Frontiers in Neural Circuits, 13:69. (2019)
- Modeling place cells and grid cells in multi-compartment environments: hippocampal-entorhinal loop as a multisensory integration circuit. bioRxiv. (2019)
- Vision loss and 12-year risk of dementia in older adults: the 3C cohort study. Eur. J. Epidemiol., 34:141-152. (2019)
- Prevalence and Associated Factors of Uncorrected Refractive Error in Older Adults in a Population-Based Study in France. JAMA Ophthalmol, 137(1):3-11. (2019)
- An alternative view of dual-tasking in older adults: Cognitive-motor interference while navigating in an ecological environment. Neurophysiologie Clinique, 49(6):414. (2019)
- Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. PLoS Comput. Biol., 15(3):e1006298. (2019)
- Healthy aging impairs photon absorption efficiency of cones. Invest. Ophthalmol. Vis. Sci., 60:544-551. (2019)
- Healthy and pathological visual aging in a French follow-up cohort study. Investigative Ophthalmology & Visual Science - ARVO, 60:5915. (2019)
- Insensitivity of place cells to the value of spatial goals in a two-choice flexible navigation task. Journal of Neuroscience, 39(13):2522-2541. (2019)
2018
- Current practice in low vision rehabilitation of age-related macular degeneration and usefulness of virtual reality as a rehabilitation tool. Journal of Aging Science, 6(2):194. (2018)
- Convis: A Toolbox to Fit and Simulate Filter-Based Models of Early Visual Processing. Frontiers in Neuroinformatics, 12:9. (2018)
- Unsupervised detection of microsaccades in high-noise regime. Journal of Vision, 18(6):1-16. (2018)
- Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. bioRxiv:347252. (2018)
- Eye-movements as a signature of age-related differences in global planning strategies for spatial navigation. bioRxiv. (2018)
- Internal noise sources limiting contrast sensitivity. Scientific Reports, 8(1):2596. (2018)
- Category structure and categorical perception jointly explained by similarity-based information theory. Entropy, 20(7):527. (2018)
2017
- Convis: A Toolbox To Fit and Simulate Filter-based Models of Early Visual Processing. bioRxiv:169284. (2017)
- Visual Impairment, Undercorrected Refractive Errors, and Activity Limitations in Older Adults: Findings From the Three-City Alienor Study. Invest. Ophthalmol. Vis. Sci., 58(4):2359-2365. (2017)
- Factorizing the motion sensitivity function into equivalent input noise and calculation efficiency. Journal of Vision, 17(1):17. (2017)
- Reducing luminance intensity can improve motion perception in noise. Scientific Reports, 7:43140. (2017)
- Adding temporally localized noise can enhance the contribution of target knowledge on contrast detection. Journal of Vision, 17:1-10. (2017)
2016
- Maximizing noise energy for noise-masking studies. Behavior Research Methods:1-13. (2016)
2015
- Spatiotemporal spike coding of behavioral adaptation in the dorsal anterior cingulate cortex. PLoS Biology, 13(8):e1002222. (2015)
2013
- Dopaminergic control of LTD/LTP threshold in prefrontal cortex. Journal of Neuroscience, 33(34):13914-26. (2013)
- Integration of sensory quanta in cuneate nucleus neurons in vivo. PloS One, 8(2):e56630. (2013)
- Coupling internal cerebellar models enhances online adaptation and supports offline consolidation in sensorimotor tasks. Frontiers in Computational Neuroscience, 7:95. (2013)
- Optic flow stimuli update anterodorsal thalamus head direction neuronal activity in rats. Journal of Neuroscience, 33(42):16790-5. (2013)
- A closed-loop neurobotic system for fine touch sensing. Journal of Neural Engineering, 10(4):046019. (2013)
- A Navigation Analysis Tool (NAT) to assess spatial behavior in open-field and structured mazes. Journal of Neuroscience Methods, 215(2):196-209. (2013)
2012
- Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory. PLoS ONE, 7(4):e32560. (2012)
2011
- The role of tonic and phasic dopamine for long-term synaptic plasticity in the prefrontal cortex: a computational model. Journal of Physiology P, 105 (1-3):45-52. (2011)
- Quantifying neurotransmission reliability through metrics-based information analysis. Neural Computation, 23(4):852-881. (2011)
- Encoding/decoding of first and second order tactile afferents in a neurorobotic application. Journal of Physiology P, 105 (1-3):25-35. (2011)
- Spatial Learning and Action Planning in a Prefrontal Cortical Network Model. PLoS Comput Biol, 7(5):e1002045. (2011)
2010
- A reinforcement learning approach to model interactions between landmarks and geometric cues during spatial learning. Brain Research, 1365:35-47. (2010)
- How synaptic release probability shapes neuronal transmission: Information theoretic analysis in a cerebellar granule cell. Neural Computation, 22(8):2031-2058. (2010)
2009
- Is there a geometric module for spatial orientation? Insights from a rodent navigation model. Psychological Review, 116(3):540-566. (2009)
- Optimal context separation of spiking haptic signals by second-order somatosensory neurons. Advances in Neural Information Processing Systems, 22. (2009)
2007
- Multimodal sensory integration and concurrent navigation strategies for spatial cognition in real and artificial organisms. Journal of Integrative Neuroscience, 6(3):327-366. (2007)
- (editors). Special Issue on Multisensory integration and parallel memory systems for spatial cognition. Journal of Integrative Neuroscience, 6(3). (2007)
2005
- A continuous attractor network model without recurrent excitation: maintenance and integration in the head direction cell system. Journal of Computational Neuroscience, 18(2):205-227. (2005)
- Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?. Nature Neuroscience, 8(10):1292-1294. (2005)
2004
- Cognitive navigation based on nonuniform Gabor space sampling, unsupervised growing networks, and reinforcement learning. IEEE Transactions on Neural Networks, 15(3):639-652. (2004)
- Rat anterodorsal thalamic head direction neurons depend upon dynamic visual signals to select anchoring landmark cues. European Journal of Neuroscience, 20(2):530-536. (2004)
- Rapid response of head direction cells to reorienting visual cues: A computational model. Neurocomputing, 58-60C:675-682. (2004)
2003
- Rapid spatial reorientation and head direction cells. Journal of Neuroscience, 23(8):3478-3482. (2003)
- Persistent activity in limbic system neurons: neurophysiological and modeling perspectives. Journal of Physiology P, 97(4-6):547-555. (2003)
2001
- Spatial orientation in navigating agents: modeling head-direction cells. Neurocomputing, 38-40(1-4):1059-1065. (2001)
2000
- Spatial cognition and neuro-mimetic navigation: a model of hippocampal place cell activity. Biological Cybernetics, 83(3):287-299. (2000)
1999
- Efficient learning of variable-resolution cognitive maps for autonomous indoor navigation. IEEE Transctions on Robotics and Automation, 15(6):990-1000. (1999)