Dr. Angelo Arleo (Director of Research CNRS)

Vision Institute
Aging in Vision and Action Lab
CNRS – INSERM – University Pierre&Marie Curie
17, rue Moreau F-75012 Paris, France
Phone: +33 (0)1 53 46 26 52
Mobile: +33 (0)6 46 84 09 56


Angelo Arleo is a Director of Research (DR2) at CNRS and a team leader at the Vision Institute, Paris, where he explores the perceptual and cognitive consequences of visual aging in humans. He is the Chairholder of the ANREssilor research chair SILVERSIGHT, which pioneers fundamental research on healthy visual aging, action and autonomy to foster innovative health care developments.

His research is primarily centred on the neural processes mediating multisensory integration, contextual learning, and spatial cognitive functions. He also focuses on adaptive neural computation and brain information processing. His approach combines experimental neuroscience and computational modelling to cross-link different organization levels, from single cell to behaviour. In addition, the validation of models through robotic implementations inscribes some aspects of his research within a neuroengineering framework.

He received a MSc degree from the University of Mathematical Science of Milan, Italy, in 1996. He joined Wulfram Gerstner’s Laboratory of Computational Neuroscience at the EPFL (Swiss Federal Institute of Technology Lausanne, Switzerland) where he received his PhD in 2000. He did a postdoctoral training in experimental neuroscience in Alain Berthoz’s Laboratory of Physiology of Perception and Action at Collège de France, Paris, from 2001-2003. He worked as an associate R&D fellow at CSL Sony, Paris, from 2004 to 2006. He received his Habilitation to Direct Research (HDR) in Life Science from the University Pierre and Marie Curie, Paris, in 2005. He was appointed as a CNRS researcher in 2006. From 2007 to 2013 he directed the Adaptive NeuroComputation (ANC) group in the unit of Neurobiology of Adaptive Processes, directed by Jean Mariani, at the University Pierre & Marie Curie, in Paris. In 2012 he was appointed as a Director of Research at CNRS. In 2014, he joined the Vision Institute, directed by José-Alain Sahel, as the head of the new Aging in Vision and Action research lab.

Keywords: Healthy aging, spatial cognition, active exploration, multisensory integration, neural coding, learning mechanisms, memory, experimental neuroscience, neurocomputational modelling, autonomy loss, visual aids, rehabilitation.


 CV and Publication List (pdf): [ download ]



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  1. Durteste M, Van Poucke L, Combariza S, Benziane B, Sahel J-A, Ramanoel S and Arleo A (2023) The vertical position of visual information conditions spatial memory performance in healthy aging. Communications Psychology, 1:2.
  2. Arleo A, Bareš M, Bernard JA, Bogoian HR, Bruchhage MMK, Bryant P, Carlson ES, Chan CCH, Chen L-K, Chung C-P, Dotson VM, Filip P, Guell X, Habas C, Jacobs HIL, Kakei S, Lee TMC, Leggio M, Misiura M, Mitoma H, Olivito G, Ramanoël S, Rezaee Z, Samstag CL, Schmahmann JD, Sekiyama K, Wong CHY, Yamashita M and Manto M (2023) Consensus Paper: Cerebellum and Ageing. The Cerebellum.
  3. Bécu M, Sheynikhovich D, Ramanoël S, Tatur G, Ozier-Lafontaine A, Authié CN, Sahel J-A and Arleo A (2023) Landmark-based spatial navigation across the human lifespan. eLife, 12:e81318.
  4. Sheynikhovich D, Otani S, Bai J and Arleo A (2023) Long-term memory, synaptic plasticity, and dopamine in rodent medial prefrontal cortex: Role in executive functions. Frontiers in Behavioral Neuroscience, (in press).


  1. Durteste M, Van Poucke L, Combariza S, Benziane B, Ramanoel S and Arleo A (2022) The vertical position of visual information conditions spatial memory performance in healthy aging. BioRxiv Preprint.
  2. Ramanoel S, Durteste M, Bizeul A, Ozier-Lafontaine A, Becu M, Sahel AJ, Habas C and Arleo A (2022) Selective neural coding of object, feature, and geometry spatial cues in humans. Human Brain Mapping.
  3. Ramanoel S, Durteste M, Perot V, Habas C and Arleo A (2022) An appraisal of the role of the neocerebellum for spatial navigation in healthy aging. The Cerebellum.
  4. Ramanoel S, Durteste M, Delaux A, de Saint Aubert J-B and Arleo A (2022) Future trends in brain aging research: visuo-cognitive functions at stake during mobility and spatial navigation. Aging Brain, 2:100034.
  5. Luque NR, Naveros F, Abadiab I, Ros E and Arleo A (2022) Electrical coupling regulated by GABAergic nucleo- olivary afferent fibres facilitate cerebellar sensory-motor adaptation. Neural Networks, 155:422-438.
  6. Luque NR, Naveros F, Sheynikhovich D, Ros E and Arleo A (2022) Computational epidemiology study of homeostatic compensation during sensorimotor aging. Neural Networks, 146:316-333.


  1. Delaux A, de Saint Aubert J-B, Ramanoel S, Bécu M, Gehrke L, Klug M, Chavarriaga R, Sahel J-A, Gramann K and Arleo A (2021) Mobile brain/body imaging of landmark-based navigation with high-density EEG. European Journal of Neuroscience, 54(12):8256-8282.
  2. Allard R, Ramanoel S, Silvestre D and Arleo A (2021) Variance-dependent neural activity in an unvoluntary averaging task. Attention, Perception, and Psychophysics, 83:1094-1105.
  3. Braham chaouche A, Rezaei M, Silvestre D, Arleo A and Allard R (2021) Functionally Assessing the Age-Related Decline in the Detection Rate of Photons by Cone Photoreceptors. Frontiers in Aging Neuroscience, 13:870.
  4. Allard R and Arleo A (2021) The false aperture problem: Global motion perception without integration of local motion signals. Psychological Review (in press).
  5. Sahel J-A, Boulanger-Scemama E, Pagot C, Arleo A, Galluppi F, Martel JN, Degli Esposti S, Delaux A, de Saint Aubert J-B, de Montleau C, Gutman E, Audo I, Duebel J, Picaud S, Dalkara D, Blouin L, M. T and Roska B (2021) Partial recovery of visual function in a blind patient after optogenetic therapy. Nature Medicine, doi:10.1038/s41591-021-01351-4.
  6. Rossi E, Eandi CM, Snyder V, Grieve K, Dansingani KK, Arleo A, Chablani J, Mrejen S, Martel J, Sahel J-A and Paques M (2021) A new method for visualizing drusen and their progression in adaptive optics ophthalmoschopy. Translation Vision Science & Technology, 10(14):19.


  1. Ramanoel S, Durteste M, Bécu M, Habas C and Arleo A (2020) Differential Brain Activity in Regions Linked to Visuospatial Processing During Landmark-Based Navigation in Young and Healthy Older Adults. Frontiers in Human Neuroscience, 14:552111.
  2. Bécu M, Sheynikhovich D, Ramanoël S, Tatur G, Ozier-Lafontaine A, Sahel J-A and Arleo A (2020) Modulation of spatial cue processing across the lifespan: a geometric polarization of space restores allocentric navigation strategies in children and older adults. bioRxiv.
  3. Bécu M, Sheynikhovich D, Tatur G, Agathos C, Bologna LL, Sahel JA and Arleo A (2020) Age-related preference for geometric spatial cues during real-world navigation. Nature Human Behaviour, 4(1):88-99.
  4. Li T, Arleo A and Sheynikhovich D (2020) A model of a panoramic visual representation in the dorsal visual pathway: the case of spatial reorientation and memory-based search. bioRxiv.
  5. Li T, Arleo A and Sheynikhovich D (2020) Modeling place cells and grid cells in multi-compartment environments: hippocampal-entorhinal loop as a multisensory integration circuit. Neural Networks, 121:37-51.
  6. Agathos CP, Ramanoel S, Bécu M, Bernardin D, Habas C and Arleo A (2020) Postural control while walking interferes with spatial learning in older adults navigating in a real Environment. Frontiers in Aging Neuroscience, 12:588653.
  7. Luque NR, Naveros F, Carrillo RR, Ros E and Arleo A (2020) A computational model of homeostatic cerebellar compensation of ageing in vestibulo-ocular reflex adaptation. bioRxiv.
  8. Naveros F, Luque NR, Ros E and Arleo A (2020) VOR adaptation on a humanoid iCub robot using a spiking cerebellar model. IEEE Trans Cybern, 50(11):4744-57.
  9. Braham chaouche A, Silvestre D, Trognon A, Arleo A and Allard R (2020) Age-related decline in motion contrast sensitivity due to lower absorption rate of cones and calculation efficiency. Scientific Reports, 10(1):16521.
  10. Traber GL, della Volpe-Waize M, Maloca P, Schmidt-Erfurth U, Rubin G, Roska B, Cordeiro MF, Otto T, Weleber R, Lesmes LA, Arleo A and Scholl HPN (2020) New technologies for outcome measures in glaucoma: review by the European Vision Institute Special Interest Focus Group. Ophthalmic Research, 63:88-96.


  1. Ramanoel S, York E, Le Petit M, Lagrené K, Habas C and Arleo A (2019) Age-related differences in functional and structural connectivity in spatial navigation brain network. Frontiers in Neural Circuits, 13:69.
  2. Li T, Arleo A and Sheynikhovich D (2019) Modeling place cells and grid cells in multi-compartment environments: hippocampal-entorhinal loop as a multisensory integration circuit. bioRxiv.
  3. Nael V, Peres K, Dartigues JF, Letenneur L, Amieva H, Arleo A, Scherlen AC, Tzourio C, Berr C, Carriere I, Delcourt C and Helmer C (2019) Vision loss and 12-year risk of dementia in older adults: the 3C cohort study. Eur. J. Epidemiol., 34:141-152.
  4. Nael V, Moreau G, Monferme S, Cougnard-Gregoire A, Scherlen AC, Arleo A, Korobelnik JF, Delcourt C and Helmer C (2019) Prevalence and Associated Factors of Uncorrected Refractive Error in Older Adults in a Population-Based Study in France. JAMA Ophthalmol, 137(1):3-11.
  5. Agathos CP, Ramanoël S, Bécu M, Baranton K, Bernardin D and Arleo A (2019) An alternative view of dual-tasking in older adults: Cognitive-motor interference while navigating in an ecological environment. Neurophysiologie Clinique, 49(6):414.
  6. Luque NR, Naveros F, Carrillo RR, Ros E and Arleo A (2019) Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. PLoS Comput. Biol., 15(3):e1006298.
  7. Silvestre D, Arleo A and Allard R (2019) Healthy aging impairs photon absorption efficiency of cones. Invest. Ophthalmol. Vis. Sci., 60:544-551.
  8. Lagrené K, Bécu M, Seiple W, Raphanel Bataille M, Combariza S, Paques M, Aubois A, Duclos B, Girmens J-F, Eandi C, Mohand-Said S and Arleo A (2019) Healthy and pathological visual aging in a French follow-up cohort study. Investigative Ophthalmology & Visual Science - ARVO, 60:5915.
  9. Duvelle E, Grieves RaHV, Poucet B, Arleo A, Jeffery K and Save E (2019) Insensitivity of place cells to the value of spatial goals in a two-choice flexible navigation task. Journal of Neuroscience, 39(13):2522-2541.


  1. Raphanel M, Shaughness G, H. Seiple W and Arleo A (2018) Current practice in low vision rehabilitation of age-related macular degeneration and usefulness of virtual reality as a rehabilitation tool. Journal of Aging Science, 6(2):194.
  2. Huth J, Masquelier T and Arleo A (2018) Convis: A Toolbox to Fit and Simulate Filter-Based Models of Early Visual Processing. Frontiers in Neuroinformatics, 12:9.
  3. Sheynikhovich D, Bécu M, Wu C and Arleo A (2018) Unsupervised detection of microsaccades in high-noise regime. Journal of Vision, 18(6):1-16.
  4. Luque NR, Naveros F, Carrillo RR, Ros E and Arleo A (2018) Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. bioRxiv:347252.
  5. Tartaglia EM, Boucly C, Tatur G and Arleo A (2018) Eye-movements as a signature of age-related differences in global planning strategies for spatial navigation. bioRxiv.
  6. Silvestre D, Arleo A and Allard R (2018) Internal noise sources limiting contrast sensitivity. Scientific Reports, 8(1):2596.
  7. Brasselet R and Arleo A (2018) Category structure and categorical perception jointly explained by similarity-based information theory. Entropy, 20(7):527.


  1. Huth J, Masquelier T and Arleo A (2017) Convis: A Toolbox To Fit and Simulate Filter-based Models of Early Visual Processing. bioRxiv:169284.
  2. Nael V, Peres K, Carriere I, Daien V, Scherlen AC, Arleo A, Korobelnik JF, Delcourt C and Helmer C (2017) Visual Impairment, Undercorrected Refractive Errors, and Activity Limitations in Older Adults: Findings From the Three-City Alienor Study. Invest. Ophthalmol. Vis. Sci., 58(4):2359-2365.
  3. Allard R and Arleo A (2017) Factorizing the motion sensitivity function into equivalent input noise and calculation efficiency. Journal of Vision, 17(1):17.
  4. Allard R and Arleo A (2017) Reducing luminance intensity can improve motion perception in noise. Scientific Reports, 7:43140.
  5. Silvestre D, Cavanagh P, Arleo A and Allard R (2017) Adding temporally localized noise can enhance the contribution of target knowledge on contrast detection. Journal of Vision, 17:1-10.


  1. Jules Étienne C, Arleo A and Allard R (2016) Maximizing noise energy for noise-masking studies. Behavior Research Methods:1-13.


  1. Logiaco L, Quilodran R, Procyk E and Arleo A (2015) Spatiotemporal spike coding of behavioral adaptation in the dorsal anterior cingulate cortex. PLoS Biology, 13(8):e1002222.


  1. Sheynikhovich D, Otani S and Arleo A (2013) Dopaminergic control of LTD/LTP threshold in prefrontal cortex. Journal of Neuroscience, 33(34):13914-26.
  2. Bengtsson F, Brasselet R, Johansson RS, Arleo A and Jörntell H (2013) Integration of sensory quanta in cuneate nucleus neurons in vivo. PloS One, 8(2):e56630.
  3. Passot J-B, Luque NR and Arleo A (2013) Coupling internal cerebellar models enhances online adaptation and supports offline consolidation in sensorimotor tasks. Frontiers in Computational Neuroscience, 7:95.
  4. Arleo A, Déjean C, Allegraud P, Khamassi M, Zugaro MB and Wiener SI (2013) Optic flow stimuli update anterodorsal thalamus head direction neuronal activity in rats. Journal of Neuroscience, 33(42):16790-5.
  5. Bologna LL*, Pinoteau J*, Passot J-B, Garrido JA, Vogel J, Ros Vidal E and Arleo A (2013) A closed-loop neurobotic system for fine touch sensing. Journal of Neural Engineering, 10(4):046019.
  6. Jarlier F, Arleo A, Petit GH, Lefort JM, Fouquet C, Burguière E and Rondi-Reig L (2013) A Navigation Analysis Tool (NAT) to assess spatial behavior in open-field and structured mazes. Journal of Neuroscience Methods, 215(2):196-209.


  1. Passot J-B, Sheynikhovich D, Duvelle E and Arleo A (2012) Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory. PLoS ONE, 7(4):e32560.


  1. Sheynikhovich D, Otani S and Arleo A (2011) The role of tonic and phasic dopamine for long-term synaptic plasticity in the prefrontal cortex: a computational model. Journal of Physiology P, 105 (1-3):45-52.
  2. Brasselet R, Johansson RS and Arleo A (2011) Quantifying neurotransmission reliability through metrics-based information analysis. Neural Computation, 23(4):852-881.
  3. Bologna LL, Pinoteau J, Brasselet R, Maggiali M and Arleo A (2011) Encoding/decoding of first and second order tactile afferents in a neurorobotic application. Journal of Physiology P, 105 (1-3):25-35.
  4. Martinet L-E, Sheynikhovich D, Benchenane K and Arleo A (2011) Spatial Learning and Action Planning in a Prefrontal Cortical Network Model. PLoS Comput Biol, 7(5):e1002045.


  1. Sheynikhovich D and Arleo A (2010) A reinforcement learning approach to model interactions between landmarks and geometric cues during spatial learning. Brain Research, 1365:35-47.
  2. Arleo A, Nieus T, Bezzi M, D'Errico A, D'Angelo E and Coenen OJM (2010) How synaptic release probability shapes neuronal transmission: Information theoretic analysis in a cerebellar granule cell. Neural Computation, 22(8):2031-2058.


  1. Sheynikhovich D, Chavarriaga R, Strösslin T, Arleo A and Gerstner W (2009) Is there a geometric module for spatial orientation? Insights from a rodent navigation model. Psychological Review, 116(3):540-566.
  2. Brasselet R, Johansson R and Arleo A (2009) Optimal context separation of spiking haptic signals by second-order somatosensory neurons. Advances in Neural Information Processing Systems, 22.


  1. Arleo A and Rondi-Reig L (2007) Multimodal sensory integration and concurrent navigation strategies for spatial cognition in real and artificial organisms. Journal of Integrative Neuroscience, 6(3):327-366.
  2. Arleo A and Chavarriaga R (2007) (editors). Special Issue on Multisensory integration and parallel memory systems for spatial cognition. Journal of Integrative Neuroscience, 6(3).


  1. Boucheny C, Brunel N and Arleo A (2005) A continuous attractor network model without recurrent excitation: maintenance and integration in the head direction cell system. Journal of Computational Neuroscience, 18(2):205-227.
  2. Burguière E, Arleo A, Hojjati M, Elgersma Y, De Zeeuw CI, Berthoz A and Rondi-Reig L (2005) Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?. Nature Neuroscience, 8(10):1292-1294.


  1. Arleo A, Smeraldi F and Gerstner W (2004) Cognitive navigation based on nonuniform Gabor space sampling, unsupervised growing networks, and reinforcement learning. IEEE Transactions on Neural Networks, 15(3):639-652.
  2. Zugaro MB, Arleo A, Déjean C, Burguière E, Khamassi M and Wiener SI (2004) Rat anterodorsal thalamic head direction neurons depend upon dynamic visual signals to select anchoring landmark cues. European Journal of Neuroscience, 20(2):530-536.
  3. Degris T, Sigaud O, Wiener SI and Arleo A (2004) Rapid response of head direction cells to reorienting visual cues: A computational model. Neurocomputing, 58-60C:675-682.


  1. Zugaro MB, Arleo A, Berthoz A and Wiener SI (2003) Rapid spatial reorientation and head direction cells. Journal of Neuroscience, 23(8):3478-3482.
  2. Wiener SI and Arleo A (2003) Persistent activity in limbic system neurons: neurophysiological and modeling perspectives. Journal of Physiology P, 97(4-6):547-555.


  1. Arleo A and Gerstner W (2001) Spatial orientation in navigating agents: modeling head-direction cells. Neurocomputing, 38-40(1-4):1059-1065.


  1. Arleo A and Gerstner W (2000) Spatial cognition and neuro-mimetic navigation: a model of hippocampal place cell activity. Biological Cybernetics, 83(3):287-299.


  1. Arleo A, del R. Millán J and Floreano D (1999) Efficient learning of variable-resolution cognitive maps for autonomous indoor navigation. IEEE Transctions on Robotics and Automation, 15(6):990-1000.